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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Pknots - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Pknots & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Pknots Multilign(seed)
MCC 0.694 > 0.683
Average MCC ± 95% Confidence Intervals 0.732 ± 0.381 > 0.649 ± 0.495
Sensitivity 0.686 > 0.636
Positive Predictive Value 0.717 < 0.750
Total TP 81 > 75
Total TN 4608 < 4621
Total FP 34 > 26
Total FP CONTRA 6 < 7
Total FP INCONS 26 > 18
Total FP COMP 2 > 1
Total FN 37 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Pknots and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Pknots and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Pknots and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Pknots and Multilign(seed)).

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Performance of Pknots - scored higher in this pairwise comparison

1. Total counts & total scores for Pknots

Total Base Pair Counts
Total TP 81
Total TN 4608
Total FP 34
Total FP CONTRA 6
Total FP INCONS 26
Total FP COMP 2
Total FN 37
Total Scores
MCC 0.694
Average MCC ± 95% Confidence Intervals 0.732 ± 0.381
Sensitivity 0.686
Positive Predictive Value 0.717
Nr of predictions 5

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2. Individual counts for Pknots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LC8_A 0.83 0.83 0.83 15 510 3 2 1 0 3
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.78 0.76 0.81 22 1506 5 1 4 0 7
4AOB_A 0.19 0.21 0.21 6 1409 23 3 19 1 23

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4621
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.683
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495
Sensitivity 0.636
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.