CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PknotsRG - scored higher in this pairwise comparison

  4. Performance of RNAsubopt - scored lower in this pairwise comparison

  5. Compile and download dataset for PknotsRG & RNAsubopt [.zip] - may take several seconds...


Overview

Metric PknotsRG RNAsubopt
MCC 0.752 > 0.738
Average MCC ± 95% Confidence Intervals 0.797 ± 0.051 > 0.770 ± 0.057
Sensitivity 0.774 > 0.757
Positive Predictive Value 0.737 > 0.726
Total TP 1575 > 1542
Total TN 149897 < 149912
Total FP 826 < 846
Total FP CONTRA 179 < 185
Total FP INCONS 384 < 396
Total FP COMP 263 < 265
Total FN 461 < 494
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of PknotsRG and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and RNAsubopt).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PknotsRG and RNAsubopt).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and RNAsubopt).

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Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP 1575
Total TN 149897
Total FP 826
Total FP CONTRA 179
Total FP INCONS 384
Total FP COMP 263
Total FN 461
Total Scores
MCC 0.752
Average MCC ± 95% Confidence Intervals 0.797 ± 0.051
Sensitivity 0.774
Positive Predictive Value 0.737
Nr of predictions 118

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.88 0.89 0.89 16 449 3 0 2 1 2
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.77 0.88 0.70 7 226 3 2 1 0 1
2KGP_A - 0.69 0.67 0.75 6 113 2 0 2 0 3
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.85 0.87 0.83 20 2000 12 4 0 8 3
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.89 0.89 0.89 17 448 2 0 2 0 2
2KUU_A 0.88 0.89 0.89 16 429 3 0 2 1 2
2KUV_A 0.89 0.89 0.89 17 420 2 0 2 0 2
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.93 0.88 1.00 7 142 0 0 0 0 1
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.66 0.61 0.73 11 513 4 2 2 0 7
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.81 0.86 0.76 25 2407 10 6 2 2 4
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.87 1.00 0.78 7 107 2 2 0 0 0
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 14 0 0 14 1
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WW9_E - 0.89 0.80 1.00 4 168 0 0 0 0 1
2WW9_F - 0.64 0.75 0.60 6 102 4 1 3 0 2
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 24 0 6 18 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.35 0.34 0.38 12 2013 21 1 19 1 23
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.25 0.27 0.25 4 1342 20 3 9 8 11
2ZZN_D 0.93 0.95 0.91 21 961 2 2 0 0 1
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.35 0.36 0.36 12 1786 21 1 20 0 21
3AKZ_H 0.46 0.50 0.43 10 1104 15 6 7 2 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 137 3 0 3 0 6
3G4S_9 0.83 0.85 0.81 22 2709 12 2 3 7 4
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.80 0.79 0.81 22 1422 6 2 3 1 6
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.54 0.60 0.50 3 223 6 1 2 3 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.21 0.21 0.24 6 1447 19 1 18 0 22
3IYQ_A 0.24 0.33 0.17 17 22340 94 45 38 11 34
3IZ4_A 0.56 0.60 0.52 57 25426 57 25 28 4 38
3IZF_C 0.75 0.77 0.73 27 2603 15 0 10 5 8
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.18 0.18 0.22 2 402 8 3 4 1 9
3J0L_2 - 0.29 0.31 0.29 8 2222 27 2 18 7 18
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_7 - 0.38 0.50 0.31 5 503 12 3 8 1 5
3J16_L 0.90 0.81 1.00 17 1142 0 0 0 0 4
3JYV_7 -0.02 0.00 0.00 0 1089 22 4 18 0 20
3JYX_3 0.77 0.80 0.75 12 2362 27 0 4 23 3
3JYX_4 0.61 0.83 0.45 10 4734 33 10 2 21 2
3KTW_C - 1.00 1.00 1.00 25 1755 7 0 0 7 0
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.93 0.86 1.00 32 2246 4 0 0 4 5
3O58_2 0.72 0.74 0.70 23 2721 19 0 10 9 8
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.18 0.25 0.14 5 4480 43 11 20 12 15
4A1C_3 0.85 0.84 0.86 31 2727 8 0 5 3 6
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 1542
Total TN 149912
Total FP 846
Total FP CONTRA 185
Total FP INCONS 396
Total FP COMP 265
Total FN 494
Total Scores
MCC 0.738
Average MCC ± 95% Confidence Intervals 0.770 ± 0.057
Sensitivity 0.757
Positive Predictive Value 0.726
Nr of predictions 118

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.95 0.91 1.00 10 176 0 0 0 0 1
2K63_A - 0.94 0.89 1.00 8 160 0 0 0 0 1
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 0.87 0.78 1.00 7 101 0 0 0 0 2
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.88 0.89 0.89 16 449 3 0 2 1 2
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - -0.03 0.00 0.00 0 229 7 1 6 0 8
2KGP_A - 1.00 1.00 1.00 9 112 0 0 0 0 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.62 0.61 0.64 14 2002 15 5 3 7 9
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.89 0.89 0.89 17 448 2 0 2 0 2
2KUU_A 0.88 0.89 0.89 16 429 3 0 2 1 2
2KUV_A 0.89 0.89 0.89 17 420 2 0 2 0 2
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.95 0.91 1.00 21 742 0 0 0 0 2
2L1F_B 0.96 0.92 1.00 22 769 0 0 0 0 2
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 0.96 0.93 1.00 13 226 0 0 0 0 1
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.85 0.86 0.83 25 2410 14 0 5 9 4
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_D - 0.09 0.10 0.11 1 732 13 2 6 5 9
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_F - 0.52 0.63 0.50 5 102 5 1 4 0 3
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.83 0.81 0.85 17 1109 4 0 3 1 4
2XXA_G 0.49 0.49 0.52 17 2012 17 1 15 1 18
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.29 0.33 0.26 5 1339 22 5 9 8 10
2ZZN_D 0.52 0.55 0.52 12 961 11 3 8 0 10
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.43 0.45 0.43 9 1106 14 3 9 2 11
3AM1_B - 1.00 1.00 1.00 29 1437 0 0 0 0 0
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.41 0.46 0.38 12 2704 25 7 13 5 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.53 0.54 0.54 15 1421 14 4 9 1 13
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.97 0.94 1.00 15 594 2 0 0 2 1
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.54 0.60 0.50 3 223 5 1 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.28 0.39 0.20 20 22342 96 41 37 18 31
3IZ4_A 0.56 0.60 0.53 57 25429 54 26 24 4 38
3IZF_C 0.89 0.91 0.86 32 2603 9 0 5 4 3
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.35 0.36 0.36 4 400 8 3 4 1 7
3J0L_2 - 0.28 0.31 0.28 8 2221 25 2 19 4 18
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_7 - -0.02 0.00 0.00 0 507 12 2 10 0 10
3J16_L 0.49 0.52 0.48 11 1136 12 3 9 0 10
3JYV_7 -0.02 0.00 0.00 0 1090 21 4 17 0 20
3JYX_3 0.77 0.80 0.75 12 2362 26 0 4 22 3
3JYX_4 0.34 0.58 0.21 7 4722 38 20 7 11 5
3KTW_C - 1.00 1.00 1.00 25 1755 8 0 0 8 0
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.66 0.68 0.65 13 715 7 0 7 0 6
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.84 0.78 0.91 29 2246 8 0 3 5 8
3O58_2 0.87 0.90 0.85 28 2721 13 0 5 8 3
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.18 0.25 0.14 5 4481 43 13 17 13 15
4A1C_3 0.85 0.84 0.86 31 2727 8 0 5 3 6
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.62 0.62 0.64 18 1409 11 4 6 1 11
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.36 0.33 0.42 5 484 7 0 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.