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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) NanoFolder
MCC 0.529 > 0.336
Average MCC ± 95% Confidence Intervals 0.487 ± 0.592 > 0.394 ± 0.460
Sensitivity 0.390 < 0.415
Positive Predictive Value 0.727 > 0.288
Total TP 32 < 34
Total TN 6933 > 6859
Total FP 16 < 101
Total FP CONTRA 0 < 25
Total FP INCONS 12 < 59
Total FP COMP 4 < 17
Total FN 50 > 48
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and NanoFolder).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 32
Total TN 6933
Total FP 16
Total FP CONTRA 0
Total FP INCONS 12
Total FP COMP 4
Total FN 50
Total Scores
MCC 0.529
Average MCC ± 95% Confidence Intervals 0.487 ± 0.592
Sensitivity 0.390
Positive Predictive Value 0.727
Nr of predictions 4

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
4A1C_2 0.50 0.25 1.00 5 4511 2 0 0 2 15
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 34
Total TN 6859
Total FP 101
Total FP CONTRA 25
Total FP INCONS 59
Total FP COMP 17
Total FN 48
Total Scores
MCC 0.336
Average MCC ± 95% Confidence Intervals 0.394 ± 0.460
Sensitivity 0.415
Positive Predictive Value 0.288
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.