CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAshapes - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAshapes & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RNAshapes Multilign(seed)
MCC 0.770 > 0.683
Average MCC ± 95% Confidence Intervals 0.783 ± 0.214 > 0.649 ± 0.495
Sensitivity 0.746 > 0.636
Positive Predictive Value 0.807 > 0.750
Total TP 88 > 75
Total TN 4612 < 4621
Total FP 23 < 26
Total FP CONTRA 8 > 7
Total FP INCONS 13 < 18
Total FP COMP 2 > 1
Total FN 30 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAshapes and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and Multilign(seed)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 88
Total TN 4612
Total FP 23
Total FP CONTRA 8
Total FP INCONS 13
Total FP COMP 2
Total FN 30
Total Scores
MCC 0.770
Average MCC ± 95% Confidence Intervals 0.783 ± 0.214
Sensitivity 0.746
Positive Predictive Value 0.807
Nr of predictions 5

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 5 0 5 0 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4621
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.683
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495
Sensitivity 0.636
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.