CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAshapes - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAshapes & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric RNAshapes RNASampler(seed)
MCC 0.805 > 0.765
Average MCC ± 95% Confidence Intervals 0.832 ± 0.123 > 0.764 ± 0.134
Sensitivity 0.826 > 0.687
Positive Predictive Value 0.789 < 0.859
Total TP 285 > 237
Total TN 23380 < 23465
Total FP 134 > 62
Total FP CONTRA 31 > 15
Total FP INCONS 45 > 24
Total FP COMP 58 > 23
Total FN 60 < 108
P-value 2.64318034126e-08

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Performance plots


  1. Comparison of performance of RNAshapes and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAshapes and RNASampler(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAshapes and RNASampler(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAshapes and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAshapes and RNASampler(seed)).

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Performance of RNAshapes - scored higher in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP 285
Total TN 23380
Total FP 134
Total FP CONTRA 31
Total FP INCONS 45
Total FP COMP 58
Total FN 60
Total Scores
MCC 0.805
Average MCC ± 95% Confidence Intervals 0.832 ± 0.123
Sensitivity 0.826
Positive Predictive Value 0.789
Nr of predictions 17

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2L1F_A 0.89 0.87 0.91 20 741 2 0 2 0 3
2L1F_B 0.98 0.96 1.00 23 768 0 0 0 0 1
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 5 0 5 0 7
3A3A_A 0.84 0.80 0.89 24 1473 3 0 3 0 6
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3JYX_4 0.61 0.83 0.45 10 4734 35 10 2 23 2
3O58_3 0.41 0.50 0.34 11 4732 38 6 15 17 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
4A1C_2 0.19 0.25 0.16 5 4484 41 11 16 14 15

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 237
Total TN 23465
Total FP 62
Total FP CONTRA 15
Total FP INCONS 24
Total FP COMP 23
Total FN 108
Total Scores
MCC 0.765
Average MCC ± 95% Confidence Intervals 0.764 ± 0.134
Sensitivity 0.687
Positive Predictive Value 0.859
Nr of predictions 17

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.94 0.89 1.00 16 451 1 0 0 1 2
2KUR_A 0.94 0.89 1.00 17 450 0 0 0 0 2
2KUU_A 0.94 0.89 1.00 16 431 1 0 0 1 2
2KUV_A 0.94 0.89 1.00 17 422 0 0 0 0 2
2KUW_A 0.94 0.89 1.00 16 454 1 0 0 1 2
2L1F_A 0.83 0.70 1.00 16 747 0 0 0 0 7
2L1F_B 0.84 0.71 1.00 17 774 0 0 0 0 7
2L94_A 0.70 0.56 0.91 10 346 2 0 1 1 8
2LC8_A -0.03 0.00 0.00 0 518 10 0 10 0 18
3A3A_A 0.77 0.60 1.00 18 1482 0 0 0 0 12
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3JYX_4 0.70 0.83 0.59 10 4739 13 6 1 6 2
3O58_3 0.54 0.50 0.58 11 4745 13 5 3 5 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.