CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAsubopt - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAsubopt & Vsfold4 [.zip] - may take several seconds...


Overview

Metric RNAsubopt Vsfold4
MCC 0.738 > 0.650
Average MCC ± 95% Confidence Intervals 0.770 ± 0.057 > 0.701 ± 0.061
Sensitivity 0.757 > 0.640
Positive Predictive Value 0.726 > 0.669
Total TP 1542 > 1303
Total TN 149912 < 150088
Total FP 846 > 814
Total FP CONTRA 185 > 181
Total FP INCONS 396 < 463
Total FP COMP 265 > 170
Total FN 494 < 733
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of RNAsubopt and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAsubopt and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAsubopt and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAsubopt and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAsubopt and Vsfold4).

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Performance of RNAsubopt - scored higher in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 1542
Total TN 149912
Total FP 846
Total FP CONTRA 185
Total FP INCONS 396
Total FP COMP 265
Total FN 494
Total Scores
MCC 0.738
Average MCC ± 95% Confidence Intervals 0.770 ± 0.057
Sensitivity 0.757
Positive Predictive Value 0.726
Nr of predictions 118

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.95 0.91 1.00 10 176 0 0 0 0 1
2K63_A - 0.94 0.89 1.00 8 160 0 0 0 0 1
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 0.87 0.78 1.00 7 101 0 0 0 0 2
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.88 0.89 0.89 16 449 3 0 2 1 2
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - -0.03 0.00 0.00 0 229 7 1 6 0 8
2KGP_A - 1.00 1.00 1.00 9 112 0 0 0 0 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.62 0.61 0.64 14 2002 15 5 3 7 9
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.89 0.89 0.89 17 448 2 0 2 0 2
2KUU_A 0.88 0.89 0.89 16 429 3 0 2 1 2
2KUV_A 0.89 0.89 0.89 17 420 2 0 2 0 2
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.95 0.91 1.00 21 742 0 0 0 0 2
2L1F_B 0.96 0.92 1.00 22 769 0 0 0 0 2
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 0.96 0.93 1.00 13 226 0 0 0 0 1
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.85 0.86 0.83 25 2410 14 0 5 9 4
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_D - 0.09 0.10 0.11 1 732 13 2 6 5 9
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_F - 0.52 0.63 0.50 5 102 5 1 4 0 3
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.83 0.81 0.85 17 1109 4 0 3 1 4
2XXA_G 0.49 0.49 0.52 17 2012 17 1 15 1 18
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.29 0.33 0.26 5 1339 22 5 9 8 10
2ZZN_D 0.52 0.55 0.52 12 961 11 3 8 0 10
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.43 0.45 0.43 9 1106 14 3 9 2 11
3AM1_B - 1.00 1.00 1.00 29 1437 0 0 0 0 0
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.41 0.46 0.38 12 2704 25 7 13 5 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.53 0.54 0.54 15 1421 14 4 9 1 13
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.97 0.94 1.00 15 594 2 0 0 2 1
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.54 0.60 0.50 3 223 5 1 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.28 0.39 0.20 20 22342 96 41 37 18 31
3IZ4_A 0.56 0.60 0.53 57 25429 54 26 24 4 38
3IZF_C 0.89 0.91 0.86 32 2603 9 0 5 4 3
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.35 0.36 0.36 4 400 8 3 4 1 7
3J0L_2 - 0.28 0.31 0.28 8 2221 25 2 19 4 18
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_7 - -0.02 0.00 0.00 0 507 12 2 10 0 10
3J16_L 0.49 0.52 0.48 11 1136 12 3 9 0 10
3JYV_7 -0.02 0.00 0.00 0 1090 21 4 17 0 20
3JYX_3 0.77 0.80 0.75 12 2362 26 0 4 22 3
3JYX_4 0.34 0.58 0.21 7 4722 38 20 7 11 5
3KTW_C - 1.00 1.00 1.00 25 1755 8 0 0 8 0
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.66 0.68 0.65 13 715 7 0 7 0 6
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.84 0.78 0.91 29 2246 8 0 3 5 8
3O58_2 0.87 0.90 0.85 28 2721 13 0 5 8 3
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.18 0.25 0.14 5 4481 43 13 17 13 15
4A1C_3 0.85 0.84 0.86 31 2727 8 0 5 3 6
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.62 0.62 0.64 18 1409 11 4 6 1 11
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.36 0.33 0.42 5 484 7 0 7 0 10

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1303
Total TN 150088
Total FP 814
Total FP CONTRA 181
Total FP INCONS 463
Total FP COMP 170
Total FN 733
Total Scores
MCC 0.650
Average MCC ± 95% Confidence Intervals 0.701 ± 0.061
Sensitivity 0.640
Positive Predictive Value 0.669
Nr of predictions 118

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.35 0.36 0.40 4 176 6 0 6 0 7
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.79 0.63 1.00 5 231 0 0 0 0 3
2KGP_A - -0.05 0.00 0.00 0 117 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.84 0.83 0.86 19 2002 9 2 1 6 4
2KU0_A - -0.04 0.00 0.00 0 283 9 2 7 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.67 0.57 0.81 13 747 3 0 3 0 10
2L1F_B 0.69 0.58 0.82 14 774 3 0 3 0 10
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.94 0.89 1.00 16 341 1 0 0 1 2
2LA5_A - 0.77 0.71 0.83 5 269 1 0 1 0 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.35 0.38 0.34 11 2408 21 7 14 0 18
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - -0.07 0.00 0.00 0 68 4 0 4 0 7
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_D - 0.12 0.10 0.17 1 735 8 1 4 3 9
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1808 27 13 14 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2016 29 1 28 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.75 0.67 0.86 12 892 4 0 2 2 6
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.18 0.20 0.19 3 1342 22 4 9 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.95 0.91 1.00 30 1789 0 0 0 0 3
3AKZ_H 0.77 0.75 0.79 15 1108 6 2 2 2 5
3AM1_B - 0.93 0.86 1.00 25 1441 0 0 0 0 4
3AMU_B 0.73 0.74 0.74 14 1138 8 0 5 3 5
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.41 0.46 0.38 12 2704 21 10 10 1 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.53 0.56 0.53 9 592 8 2 6 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.28 0.25 0.35 7 1452 13 2 11 0 21
3IYQ_A 0.27 0.35 0.21 18 22353 80 40 29 11 33
3IZ4_A 0.39 0.39 0.39 37 25441 63 15 43 5 58
3IZF_C 0.85 0.83 0.88 29 2607 6 0 4 2 6
3J0L_h - 0.44 0.38 0.52 12 2117 11 2 9 0 20
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_2 - 0.47 0.46 0.50 12 2226 18 1 11 6 14
3J0L_1 - 0.26 0.23 0.33 3 475 7 2 4 1 10
3J0L_7 - 0.69 0.70 0.70 7 509 4 1 2 1 3
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_3 0.64 0.67 0.63 10 2362 16 5 1 10 5
3JYX_4 0.19 0.25 0.15 3 4736 33 9 8 16 9
3KTW_C - 0.43 0.40 0.48 10 1759 15 2 9 4 15
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.33 0.32 0.35 14 3674 26 2 24 0 30
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.57 0.33 1.00 1 215 3 0 0 3 2
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_2 0.53 0.52 0.55 16 2725 16 3 10 3 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.66 0.69 0.65 11 1276 10 3 3 4 5
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.