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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RSpredict(20) NanoFolder
MCC 0.414 > 0.389
Average MCC ± 95% Confidence Intervals 0.420 ± 0.258 > 0.405 ± 0.473
Sensitivity 0.356 < 0.475
Positive Predictive Value 0.493 > 0.331
Total TP 36 < 48
Total TN 9139 > 9067
Total FP 46 < 114
Total FP CONTRA 13 < 33
Total FP INCONS 24 < 64
Total FP COMP 9 < 17
Total FN 65 > 53
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and NanoFolder).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 36
Total TN 9139
Total FP 46
Total FP CONTRA 13
Total FP INCONS 24
Total FP COMP 9
Total FN 65
Total Scores
MCC 0.414
Average MCC ± 95% Confidence Intervals 0.420 ± 0.258
Sensitivity 0.356
Positive Predictive Value 0.493
Nr of predictions 4

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.60 0.49 0.75 18 2739 8 0 6 2 19
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.