CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Sfold - scored higher in this pairwise comparison

  4. Performance of RNAfold - scored lower in this pairwise comparison

  5. Compile and download dataset for Sfold & RNAfold [.zip] - may take several seconds...


Overview

Metric Sfold RNAfold
MCC 0.633 > 0.604
Average MCC ± 95% Confidence Intervals 0.796 ± 0.051 > 0.787 ± 0.054
Sensitivity 0.631 < 0.641
Positive Predictive Value 0.636 > 0.570
Total TP 2581 < 2621
Total TN 5048181 > 5047640
Total FP 2039 < 2593
Total FP CONTRA 416 < 592
Total FP INCONS 1061 < 1386
Total FP COMP 562 < 615
Total FN 1510 > 1470
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Sfold and RNAfold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and RNAfold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Sfold and RNAfold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and RNAfold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and RNAfold).

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Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP 2581
Total TN 5048181
Total FP 2039
Total FP CONTRA 416
Total FP INCONS 1061
Total FP COMP 562
Total FN 1510
Total Scores
MCC 0.633
Average MCC ± 95% Confidence Intervals 0.796 ± 0.051
Sensitivity 0.631
Positive Predictive Value 0.636
Nr of predictions 121

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.94 0.94 0.94 17 449 2 0 1 1 1
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - -0.03 0.00 0.00 0 229 7 1 6 0 8
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.95 0.95 0.95 18 448 1 0 1 0 1
2KUU_A 0.94 0.94 0.94 17 429 2 0 1 1 1
2KUV_A 0.94 0.95 0.95 18 420 1 0 1 0 1
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.46 0.39 0.58 7 516 5 0 5 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.95 0.90 1.00 26 2414 6 0 0 6 3
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WDL_A - 0.50 0.50 0.50 392 1444543 429 62 325 42 396
2WRQ_Y 0.94 0.89 1.00 8 1144 14 0 0 14 1
2WW9_E - 0.89 0.80 1.00 4 168 0 0 0 0 1
2WW9_D - 0.31 0.10 1.00 1 740 3 0 0 3 9
2WW9_F - 0.64 0.75 0.60 6 102 4 1 3 0 2
2WWQ_V 1.00 1.00 1.00 19 1185 2 0 0 2 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.85 0.81 0.89 17 1110 3 0 2 1 4
2XXA_G 0.37 0.34 0.41 12 2016 18 1 16 1 23
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 0.75 0.57 1.00 4 540 0 0 0 0 3
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.07 0.07 0.10 1 1348 17 3 6 8 14
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.67 0.64 0.72 21 1790 9 0 8 1 12
3AKZ_H 0.49 0.50 0.50 10 1107 12 3 7 2 10
3AM1_B - 0.75 0.76 0.76 22 1437 7 3 4 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.78 0.77 0.80 20 2711 12 2 3 7 6
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.86 0.79 0.96 22 1426 2 1 0 1 6
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.66 0.60 0.75 3 225 1 0 1 0 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.25 0.33 0.19 17 22350 86 39 34 13 34
3IZ4_A 0.59 0.56 0.63 53 25452 34 14 17 3 42
3IZF_C 0.89 0.91 0.86 32 2603 8 0 5 3 3
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.44 0.42 0.48 11 2227 19 0 12 7 15
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_7 - -0.01 0.00 0.00 0 516 3 1 2 0 10
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_1 - 0.83 0.77 0.91 10 473 5 0 1 4 3
3J0L_a - 0.55 0.64 0.50 7 397 8 5 2 1 4
3J16_L 0.34 0.33 0.37 7 1140 12 0 12 0 14
3JYV_7 -0.02 0.00 0.00 0 1095 16 2 14 0 20
3JYX_3 0.77 0.80 0.75 12 2362 24 0 4 20 3
3JYX_5 - 0.42 0.46 0.38 223 1968418 588 172 189 227 258
3JYX_4 0.68 0.83 0.56 10 4738 23 7 1 15 2
3KIY_A - 0.53 0.51 0.56 403 1485155 373 56 266 51 383
3KTW_C - 0.98 0.96 1.00 24 1756 8 0 0 8 1
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.96 0.93 1.00 41 3673 4 0 0 4 3
3NKB_B - 0.75 0.74 0.78 14 717 4 0 4 0 5
3NMU_E - 1.00 1.00 1.00 3 213 4 0 0 4 0
3NPB_A 0.85 0.78 0.94 29 2247 7 0 2 5 8
3O58_2 0.87 0.90 0.85 28 2721 11 0 5 6 3
3O58_3 0.51 0.50 0.52 11 4743 18 2 8 8 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.82 0.80 0.85 40 4793 9 2 5 2 10
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.78 0.72 0.84 21 1508 4 2 2 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 2 0 0 2 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.60 0.50 0.73 8 1282 7 3 0 4 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_3 0.83 0.81 0.86 30 2728 7 0 5 2 7
4A1C_2 0.21 0.25 0.19 5 4489 34 8 14 12 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10

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Performance of RNAfold - scored lower in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 2621
Total TN 5047640
Total FP 2593
Total FP CONTRA 592
Total FP INCONS 1386
Total FP COMP 615
Total FN 1470
Total Scores
MCC 0.604
Average MCC ± 95% Confidence Intervals 0.787 ± 0.054
Sensitivity 0.641
Positive Predictive Value 0.570
Nr of predictions 121

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - -0.03 0.00 0.00 0 229 7 1 6 0 8
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 1.00 1.00 1.00 12 280 0 0 0 0 0
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.64 0.61 0.69 11 512 5 0 5 0 7
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 1.00 1.00 1.00 29 2411 8 0 0 8 0
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WDL_A - 0.49 0.52 0.47 408 1444460 493 86 368 39 380
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_E - 0.89 0.80 1.00 4 168 0 0 0 0 1
2WW9_D - 0.08 0.10 0.08 1 729 15 2 9 4 9
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.35 0.34 0.38 12 2013 21 1 19 1 23
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 0.33 0.43 0.27 3 533 11 3 5 3 4
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.25 0.27 0.25 4 1342 20 3 9 8 11
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.35 0.36 0.36 12 1786 22 1 20 1 21
3AKZ_H 0.48 0.50 0.48 10 1106 13 4 7 2 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.78 0.77 0.80 20 2711 12 2 3 7 6
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.81 0.79 0.85 22 1423 5 2 2 1 6
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 5 0 2 3 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.24 0.33 0.17 17 22340 95 45 38 12 34
3IZ4_A 0.56 0.60 0.52 57 25426 57 26 27 4 38
3IZF_C 0.75 0.77 0.73 27 2603 15 0 10 5 8
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.30 0.31 0.31 8 2224 25 2 16 7 18
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_7 - -0.02 0.00 0.00 0 507 12 2 10 0 10
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_a - 0.18 0.18 0.22 2 402 8 3 4 1 9
3J16_L 0.90 0.81 1.00 17 1142 0 0 0 0 4
3JYV_7 -0.02 0.00 0.00 0 1089 22 4 18 0 20
3JYX_3 0.77 0.80 0.75 12 2362 27 0 4 23 3
3JYX_5 - 0.36 0.46 0.29 220 1968243 783 251 288 244 261
3JYX_4 0.61 0.83 0.45 10 4734 33 10 2 21 2
3KIY_A - 0.50 0.53 0.48 414 1485013 501 90 363 48 372
3KTW_C - 0.96 0.96 0.96 24 1755 9 0 1 8 1
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.91 0.86 0.97 32 2245 5 1 0 4 5
3O58_2 0.72 0.74 0.70 23 2721 19 0 10 9 8
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_3 0.88 0.86 0.89 32 2727 7 0 4 3 5
4A1C_2 0.19 0.25 0.15 5 4482 43 11 18 14 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.37 0.33 0.45 5 485 7 0 6 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.