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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric TurboFold(20) NanoFolder
MCC 0.643 > 0.389
Average MCC ± 95% Confidence Intervals 0.620 ± 0.439 > 0.405 ± 0.473
Sensitivity 0.614 > 0.475
Positive Predictive Value 0.681 > 0.331
Total TP 62 > 48
Total TN 9121 > 9067
Total FP 41 < 114
Total FP CONTRA 9 < 33
Total FP INCONS 20 < 64
Total FP COMP 12 < 17
Total FN 39 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and NanoFolder).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 62
Total TN 9121
Total FP 41
Total FP CONTRA 9
Total FP INCONS 20
Total FP COMP 12
Total FN 39
Total Scores
MCC 0.643
Average MCC ± 95% Confidence Intervals 0.620 ± 0.439
Sensitivity 0.614
Positive Predictive Value 0.681
Nr of predictions 4

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.86 0.84 0.89 31 2728 6 0 4 2 6
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.