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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Multilign(seed)
MCC 0.707 > 0.678
Average MCC ± 95% Confidence Intervals 0.698 ± 0.101 < 0.711 ± 0.265
Sensitivity 0.543 = 0.543
Positive Predictive Value 0.926 > 0.852
Total TP 75 = 75
Total TN 11407 > 11400
Total FP 7 < 14
Total FP CONTRA 0 < 1
Total FP INCONS 6 < 12
Total FP COMP 1 = 1
Total FN 63 = 63
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 75
Total TN 11407
Total FP 7
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 1
Total FN 63
Total Scores
MCC 0.707
Average MCC ± 95% Confidence Intervals 0.698 ± 0.101
Sensitivity 0.543
Positive Predictive Value 0.926
Nr of predictions 4

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.61 0.55 0.69 11 974 5 0 5 0 9
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.71 0.52 0.96 22 3893 1 0 1 0 20
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 11400
Total FP 14
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 1
Total FN 63
Total Scores
MCC 0.678
Average MCC ± 95% Confidence Intervals 0.711 ± 0.265
Sensitivity 0.543
Positive Predictive Value 0.852
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.