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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(seed) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(seed) Multilign(seed)
MCC 0.657 > 0.593
Average MCC ± 95% Confidence Intervals 0.552 ± 0.400 < 0.567 ± 0.439
Sensitivity 0.481 > 0.475
Positive Predictive Value 0.905 > 0.750
Total TP 76 > 75
Total TN 12944 > 12928
Total FP 9 < 26
Total FP CONTRA 0 < 2
Total FP INCONS 8 < 23
Total FP COMP 1 = 1
Total FN 82 < 83
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(seed) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and Multilign(seed)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 76
Total TN 12944
Total FP 9
Total FP CONTRA 0
Total FP INCONS 8
Total FP COMP 1
Total FN 82
Total Scores
MCC 0.657
Average MCC ± 95% Confidence Intervals 0.552 ± 0.400
Sensitivity 0.481
Positive Predictive Value 0.905
Nr of predictions 5

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.53 0.50 0.59 10 973 7 0 7 0 10
2LC8_A 0.00 0.00 0.00 0 1540 0 0 0 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.71 0.52 0.96 22 3893 1 0 1 0 20
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 12928
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 83
Total Scores
MCC 0.593
Average MCC ± 95% Confidence Intervals 0.567 ± 0.439
Sensitivity 0.475
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.