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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidFold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidFold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidFold Multilign(seed)
MCC 0.625 > 0.593
Average MCC ± 95% Confidence Intervals 0.641 ± 0.247 > 0.567 ± 0.439
Sensitivity 0.500 > 0.475
Positive Predictive Value 0.790 > 0.750
Total TP 79 > 75
Total TN 12928 = 12928
Total FP 22 < 26
Total FP CONTRA 3 > 2
Total FP INCONS 18 < 23
Total FP COMP 1 = 1
Total FN 79 < 83
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidFold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and Multilign(seed)).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 79
Total TN 12928
Total FP 22
Total FP CONTRA 3
Total FP INCONS 18
Total FP COMP 1
Total FN 79
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.641 ± 0.247
Sensitivity 0.500
Positive Predictive Value 0.790
Nr of predictions 5

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.90 0.95 18 971 1 0 1 0 2
2LC8_A 0.49 0.35 0.70 7 1530 3 1 2 0 13
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
4AOB_A 0.45 0.33 0.61 14 4348 10 1 8 1 28

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 12928
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 83
Total Scores
MCC 0.593
Average MCC ± 95% Confidence Intervals 0.567 ± 0.439
Sensitivity 0.475
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.92 0.85 1.00 17 973 0 0 0 0 3
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.