CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of MaxExpect - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & MaxExpect [.zip] - may take several seconds...


Overview

Metric ContextFold MaxExpect
MCC 0.705 > 0.608
Average MCC ± 95% Confidence Intervals 0.739 ± 0.100 > 0.673 ± 0.129
Sensitivity 0.594 > 0.536
Positive Predictive Value 0.843 > 0.696
Total TP 360 > 325
Total TN 64163 > 64123
Total FP 90 < 166
Total FP CONTRA 6 < 16
Total FP INCONS 61 < 126
Total FP COMP 23 < 24
Total FN 246 < 281
P-value 3.56938820447e-08

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Performance plots


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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 360
Total TN 64163
Total FP 90
Total FP CONTRA 6
Total FP INCONS 61
Total FP COMP 23
Total FN 246
Total Scores
MCC 0.705
Average MCC ± 95% Confidence Intervals 0.739 ± 0.100
Sensitivity 0.594
Positive Predictive Value 0.843
Nr of predictions 30

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.55 0.50 0.63 10 1524 6 0 6 0 10
2LDL_A - 0.90 0.82 1.00 9 342 0 0 0 0 2
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 0.93 0.88 1.00 7 344 2 0 0 2 1
2LK3_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2LKR_A - 0.65 0.56 0.76 22 6076 9 0 7 2 17
2LQZ_A - 0.80 0.73 0.89 8 342 1 1 0 0 3
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.71 0.56 0.90 9 1118 1 0 1 0 7
3J0L_1 - 0.70 0.58 0.85 11 1212 3 0 2 1 8
3J0L_h - 0.82 0.67 1.00 29 6076 2 0 0 2 14
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_g - -0.01 0.00 0.00 0 462 3 1 2 0 4
3J0L_2 - 0.64 0.61 0.69 20 6187 11 2 7 2 13
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 0 0 0 0 1
3TS0_U - 1.00 1.00 1.00 6 247 0 0 0 0 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.75 0.57 1.00 21 3139 0 0 0 0 16
3UZL_B 0.72 0.54 0.95 20 3549 1 0 1 0 17
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
4A1C_3 0.78 0.63 0.97 34 7105 1 0 1 0 20
4A1C_2 0.20 0.15 0.28 5 11763 26 0 13 13 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 325
Total TN 64123
Total FP 166
Total FP CONTRA 16
Total FP INCONS 126
Total FP COMP 24
Total FN 281
Total Scores
MCC 0.608
Average MCC ± 95% Confidence Intervals 0.673 ± 0.129
Sensitivity 0.536
Positive Predictive Value 0.696
Nr of predictions 30

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.81 0.74 0.88 29 6072 6 0 4 2 10
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.39 0.31 0.50 5 1118 5 2 3 0 11
3J0L_1 - 0.76 0.63 0.92 12 1212 2 0 1 1 7
3J0L_h - 0.81 0.65 1.00 28 6077 2 0 0 2 15
3J0L_7 - -0.01 0.00 0.00 0 1213 12 0 12 0 17
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_2 - 0.25 0.24 0.26 8 6185 25 2 21 2 25
3J16_L 0.29 0.23 0.37 7 2756 12 0 12 0 23
3SN2_B 1.00 1.00 1.00 12 394 0 0 0 0 0
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.45 0.35 0.59 13 3138 9 1 8 0 24
3UZL_B 0.77 0.62 0.96 23 3546 1 0 1 0 14
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A1C_2 0.14 0.15 0.14 5 11746 41 4 26 11 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.