CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of UNAFold - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & UNAFold [.zip] - may take several seconds...


Overview

Metric ContextFold UNAFold
MCC 0.705 > 0.600
Average MCC ± 95% Confidence Intervals 0.739 ± 0.100 > 0.676 ± 0.121
Sensitivity 0.594 > 0.538
Positive Predictive Value 0.843 > 0.676
Total TP 360 > 326
Total TN 64163 > 64108
Total FP 90 < 178
Total FP CONTRA 6 < 20
Total FP INCONS 61 < 136
Total FP COMP 23 > 22
Total FN 246 < 280
P-value 5.23657817852e-08

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Performance plots


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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 360
Total TN 64163
Total FP 90
Total FP CONTRA 6
Total FP INCONS 61
Total FP COMP 23
Total FN 246
Total Scores
MCC 0.705
Average MCC ± 95% Confidence Intervals 0.739 ± 0.100
Sensitivity 0.594
Positive Predictive Value 0.843
Nr of predictions 30

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.55 0.50 0.63 10 1524 6 0 6 0 10
2LDL_A - 0.90 0.82 1.00 9 342 0 0 0 0 2
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 0.93 0.88 1.00 7 344 2 0 0 2 1
2LK3_A - 0.89 0.80 1.00 8 268 0 0 0 0 2
2LKR_A - 0.65 0.56 0.76 22 6076 9 0 7 2 17
2LQZ_A - 0.80 0.73 0.89 8 342 1 1 0 0 3
2LWK_A - 0.88 0.85 0.92 11 484 1 0 1 0 2
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.71 0.56 0.90 9 1118 1 0 1 0 7
3J0L_1 - 0.70 0.58 0.85 11 1212 3 0 2 1 8
3J0L_h - 0.82 0.67 1.00 29 6076 2 0 0 2 14
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_g - -0.01 0.00 0.00 0 462 3 1 2 0 4
3J0L_2 - 0.64 0.61 0.69 20 6187 11 2 7 2 13
3J16_L 0.75 0.57 1.00 17 2758 0 0 0 0 13
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 0 0 0 0 1
3TS0_U - 1.00 1.00 1.00 6 247 0 0 0 0 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.75 0.57 1.00 21 3139 0 0 0 0 16
3UZL_B 0.72 0.54 0.95 20 3549 1 0 1 0 17
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
4A1C_3 0.78 0.63 0.97 34 7105 1 0 1 0 20
4A1C_2 0.20 0.15 0.28 5 11763 26 0 13 13 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 326
Total TN 64108
Total FP 178
Total FP CONTRA 20
Total FP INCONS 136
Total FP COMP 22
Total FN 280
Total Scores
MCC 0.600
Average MCC ± 95% Confidence Intervals 0.676 ± 0.121
Sensitivity 0.538
Positive Predictive Value 0.676
Nr of predictions 30

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2LDL_A - 0.90 0.82 1.00 9 342 1 0 0 1 2
2LHP_A - 0.97 0.94 1.00 15 651 0 0 0 0 1
2LI4_A - 0.93 0.88 1.00 14 482 0 0 0 0 2
2LJJ_A - 1.00 1.00 1.00 8 343 2 0 0 2 0
2LK3_A - 0.95 0.90 1.00 9 267 0 0 0 0 1
2LKR_A - 0.93 0.87 1.00 34 6071 1 0 0 1 5
2LQZ_A - 0.85 0.82 0.90 9 341 1 1 0 0 2
2LWK_A - 0.83 0.77 0.91 10 485 1 0 1 0 3
3J0L_8 - 0.93 0.88 1.00 7 183 0 0 0 0 1
3J0L_a - 0.51 0.50 0.53 8 1113 7 3 4 0 8
3J0L_1 - 0.70 0.58 0.85 11 1212 2 0 2 0 8
3J0L_h - 0.75 0.60 0.93 26 6077 4 0 2 2 17
3J0L_7 - 0.48 0.41 0.58 7 1213 5 0 5 0 10
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_2 - 0.25 0.24 0.26 8 6185 25 2 21 2 25
3J16_L 0.26 0.23 0.30 7 2752 16 1 15 0 23
3SN2_B 0.96 0.92 1.00 11 395 0 0 0 0 1
3TRZ_Z - 0.91 0.83 1.00 5 205 1 0 0 1 1
3TS0_U - 1.00 1.00 1.00 6 247 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 271 0 0 0 0 0
3U4M_B - 0.38 0.32 0.46 12 3134 14 0 14 0 25
3UZL_B 0.48 0.38 0.61 14 3547 9 0 9 0 23
3VJR_D - 0.96 0.92 1.00 12 618 0 0 0 0 1
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4A1C_2 0.14 0.15 0.14 5 11745 42 5 26 11 28
4A4U_A - 1.00 1.00 1.00 9 222 0 0 0 0 0
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 1 6 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.