CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of HotKnots - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for HotKnots & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric HotKnots RNASampler(seed)
MCC 0.699 > 0.673
Average MCC ± 95% Confidence Intervals 0.762 ± 0.144 > 0.690 ± 0.136
Sensitivity 0.653 > 0.535
Positive Predictive Value 0.753 < 0.851
Total TP 293 > 240
Total TN 60970 < 61077
Total FP 120 > 59
Total FP CONTRA 22 > 4
Total FP INCONS 74 > 38
Total FP COMP 24 > 17
Total FN 156 < 209
P-value 1.52299983238e-08

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Performance plots


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Performance of HotKnots - scored higher in this pairwise comparison

1. Total counts & total scores for HotKnots

Total Base Pair Counts
Total TP 293
Total TN 60970
Total FP 120
Total FP CONTRA 22
Total FP INCONS 74
Total FP COMP 24
Total FN 156
Total Scores
MCC 0.699
Average MCC ± 95% Confidence Intervals 0.762 ± 0.144
Sensitivity 0.653
Positive Predictive Value 0.753
Nr of predictions 17

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2. Individual counts for HotKnots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.97 0.95 1.00 18 1110 1 0 0 1 1
2KUR_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2KUU_A 0.92 0.86 1.00 18 1110 1 0 0 1 3
2KUV_A 0.93 0.86 1.00 19 1109 0 0 0 0 3
2KUW_A 0.95 0.90 1.00 19 1109 0 0 0 0 2
2L1F_A 0.98 0.96 1.00 23 2057 0 0 0 0 1
2L1F_B 0.98 0.96 1.00 24 2121 0 0 0 0 1
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
3A3A_A 0.87 0.76 1.00 28 3627 0 0 0 0 9
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3JYX_4 0.32 0.30 0.33 10 12216 31 5 15 11 23
3O58_3 0.23 0.26 0.21 9 12360 34 10 24 0 26
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
4A1C_2 0.14 0.15 0.14 5 11745 42 6 25 11 28

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 240
Total TN 61077
Total FP 59
Total FP CONTRA 4
Total FP INCONS 38
Total FP COMP 17
Total FN 209
Total Scores
MCC 0.673
Average MCC ± 95% Confidence Intervals 0.690 ± 0.136
Sensitivity 0.535
Positive Predictive Value 0.851
Nr of predictions 17

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2KE6_A 0.92 0.84 1.00 16 1112 1 0 0 1 3
2KUR_A 0.90 0.81 1.00 17 1111 0 0 0 0 4
2KUU_A 0.87 0.76 1.00 16 1112 1 0 0 1 5
2KUV_A 0.88 0.77 1.00 17 1111 0 0 0 0 5
2KUW_A 0.90 0.81 1.00 17 1111 0 0 0 0 4
2L1F_A 0.81 0.67 1.00 16 2064 0 0 0 0 8
2L1F_B 0.82 0.68 1.00 17 2128 0 0 0 0 8
2L94_A 0.71 0.55 0.92 11 978 1 0 1 0 9
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3A3A_A 0.70 0.49 1.00 18 3637 0 0 0 0 19
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3JYX_4 0.39 0.30 0.50 10 12226 13 2 8 3 23
3O58_3 0.45 0.34 0.60 12 12383 12 2 6 4 23
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.