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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidAlifold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & CentroidAlifold(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) CentroidAlifold(20)
MCC 0.678 > 0.650
Average MCC ± 95% Confidence Intervals 0.625 ± 0.179 > 0.613 ± 0.256
Sensitivity 0.557 > 0.473
Positive Predictive Value 0.830 < 0.898
Total TP 93 > 79
Total TN 25781 < 25805
Total FP 26 > 13
Total FP CONTRA 2 > 1
Total FP INCONS 17 > 8
Total FP COMP 7 > 4
Total FN 74 < 88
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and CentroidAlifold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CentroidAlifold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 93
Total TN 25781
Total FP 26
Total FP CONTRA 2
Total FP INCONS 17
Total FP COMP 7
Total FN 74
Total Scores
MCC 0.678
Average MCC ± 95% Confidence Intervals 0.625 ± 0.179
Sensitivity 0.557
Positive Predictive Value 0.830
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.83 0.70 0.97 38 7101 1 0 1 0 16
4A1C_2 0.57 0.45 0.71 15 11760 12 0 6 6 18
4AOB_A 0.72 0.57 0.92 24 4345 3 0 2 1 18
4ENB_A 0.50 0.42 0.62 8 1262 5 1 4 0 11
4ENC_A 0.50 0.42 0.62 8 1313 5 1 4 0 11

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Performance of CentroidAlifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 79
Total TN 25805
Total FP 13
Total FP CONTRA 1
Total FP INCONS 8
Total FP COMP 4
Total FN 88
Total Scores
MCC 0.650
Average MCC ± 95% Confidence Intervals 0.613 ± 0.256
Sensitivity 0.473
Positive Predictive Value 0.898
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.76 0.63 0.92 34 7103 4 0 3 1 20
4A1C_2 0.26 0.15 0.45 5 11770 8 1 5 2 28
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.60 0.37 1.00 7 1319 0 0 0 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.