CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ProbKnot - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ProbKnot & Carnac(20) [.zip] - may take several seconds...


Overview

Metric ProbKnot Carnac(20)
MCC 0.586 > 0.558
Average MCC ± 95% Confidence Intervals 0.605 ± 0.109 > 0.473 ± 0.136
Sensitivity 0.529 > 0.339
Positive Predictive Value 0.653 < 0.924
Total TP 400 > 256
Total TN 165304 < 165640
Total FP 267 > 31
Total FP CONTRA 31 > 1
Total FP INCONS 182 > 20
Total FP COMP 54 > 10
Total FN 356 < 500
P-value 3.10499527239e-08

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Performance plots


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Performance of ProbKnot - scored higher in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 400
Total TN 165304
Total FP 267
Total FP CONTRA 31
Total FP INCONS 182
Total FP COMP 54
Total FN 356
Total Scores
MCC 0.586
Average MCC ± 95% Confidence Intervals 0.605 ± 0.109
Sensitivity 0.529
Positive Predictive Value 0.653
Nr of predictions 18

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2XKV_B 0.51 0.50 0.53 10 4541 24 0 9 15 10
2XQD_Y 0.90 0.81 1.00 22 2828 1 0 0 1 5
2XXA_G 0.26 0.24 0.29 10 5116 25 1 24 0 32
3AMU_B 0.65 0.59 0.73 16 2981 8 0 6 2 11
3IZ4_A 0.52 0.46 0.60 61 70774 46 6 35 5 71
3IZF_C 0.72 0.61 0.85 33 6864 6 0 6 0 21
3NPB_A 0.72 0.61 0.85 28 6988 8 1 4 3 18
3O58_3 0.31 0.34 0.29 12 12362 41 4 25 12 23
3O58_2 0.76 0.76 0.76 29 7222 10 3 6 1 9
3PDR_A 0.74 0.64 0.85 46 12826 10 1 7 2 26
3RKF_A 0.73 0.59 0.91 20 2189 2 1 1 0 14
3SD1_A 0.55 0.48 0.65 20 3885 11 2 9 0 22
4A1C_3 0.73 0.61 0.87 33 7102 6 1 4 1 21
4A1C_2 0.13 0.15 0.12 5 11738 49 7 31 11 28
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.73 0.58 0.92 11 1263 1 1 0 0 8
4ENC_A 0.45 0.42 0.50 8 1310 8 1 7 0 11

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 256
Total TN 165640
Total FP 31
Total FP CONTRA 1
Total FP INCONS 20
Total FP COMP 10
Total FN 500
Total Scores
MCC 0.558
Average MCC ± 95% Confidence Intervals 0.473 ± 0.136
Sensitivity 0.339
Positive Predictive Value 0.924
Nr of predictions 18

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.00 0.00 0.00 0 990 0 0 0 0 20
2XKV_B 0.32 0.10 1.00 2 4558 1 0 0 1 18
2XQD_Y 0.79 0.63 1.00 17 2833 0 0 0 0 10
2XXA_G 0.27 0.07 1.00 3 5148 0 0 0 0 39
3AMU_B 0.69 0.59 0.80 16 2983 6 0 4 2 11
3IZ4_A 0.47 0.23 0.94 31 70843 2 0 2 0 101
3IZF_C 0.73 0.56 0.97 30 6872 1 0 1 0 24
3NPB_A 0.44 0.20 1.00 9 7012 2 0 0 2 37
3O58_3 0.51 0.26 1.00 9 12394 0 0 0 0 26
3O58_2 0.83 0.71 0.96 27 7232 2 0 1 1 11
3PDR_A 0.62 0.40 0.97 29 12850 3 0 1 2 43
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.