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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RSpredict(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for RSpredict(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric RSpredict(20) NanoFolder
MCC 0.337 > 0.316
Average MCC ± 95% Confidence Intervals 0.349 ± 0.223 > 0.345 ± 0.403
Sensitivity 0.243 < 0.324
Positive Predictive Value 0.474 > 0.316
Total TP 36 < 48
Total TN 24542 > 24466
Total FP 46 < 114
Total FP CONTRA 6 < 15
Total FP INCONS 34 < 89
Total FP COMP 6 < 10
Total FN 112 > 100
P-value 0.0

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Performance plots


  1. Comparison of performance of RSpredict(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RSpredict(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RSpredict(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RSpredict(20) and NanoFolder).

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Performance of RSpredict(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 36
Total TN 24542
Total FP 46
Total FP CONTRA 6
Total FP INCONS 34
Total FP COMP 6
Total FN 112
Total Scores
MCC 0.337
Average MCC ± 95% Confidence Intervals 0.349 ± 0.223
Sensitivity 0.243
Positive Predictive Value 0.474
Nr of predictions 4

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.48 0.33 0.69 18 7114 8 0 8 0 36
4A1C_2 0.19 0.18 0.20 6 11751 30 6 18 6 27
4AOB_A 0.28 0.14 0.55 6 4360 5 0 5 0 36
4ENC_A 0.45 0.32 0.67 6 1317 3 0 3 0 13

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 24466
Total FP 114
Total FP CONTRA 15
Total FP INCONS 89
Total FP COMP 10
Total FN 100
Total Scores
MCC 0.316
Average MCC ± 95% Confidence Intervals 0.345 ± 0.403
Sensitivity 0.324
Positive Predictive Value 0.316
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.48 0.46 0.51 25 7091 24 2 22 0 29
4A1C_2 0.00 0.00 0.00 0 11728 61 12 41 8 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.