CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of UNAFold - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for UNAFold & Carnac(20) [.zip] - may take several seconds...


Overview

Metric UNAFold Carnac(20)
MCC 0.585 > 0.582
Average MCC ± 95% Confidence Intervals 0.600 ± 0.084 > 0.536 ± 0.094
Sensitivity 0.512 > 0.371
Positive Predictive Value 0.672 < 0.915
Total TP 546 > 396
Total TN 209294 < 209673
Total FP 344 > 59
Total FP CONTRA 34 > 8
Total FP INCONS 232 > 29
Total FP COMP 78 > 22
Total FN 520 < 670
P-value 0.0014549156141

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Performance plots


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Performance of UNAFold - scored higher in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 546
Total TN 209294
Total FP 344
Total FP CONTRA 34
Total FP INCONS 232
Total FP COMP 78
Total FN 520
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.600 ± 0.084
Sensitivity 0.512
Positive Predictive Value 0.672
Nr of predictions 28

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.95 0.91 1.00 10 396 0 0 0 0 1
2L94_A 0.97 0.95 1.00 19 971 0 0 0 0 1
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2XKV_B 0.47 0.45 0.50 9 4542 21 0 9 12 11
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
2XXA_G 0.34 0.31 0.39 13 5118 20 1 19 0 29
3A2K_C 0.42 0.39 0.46 11 2902 13 2 11 0 17
3AMU_B 0.70 0.59 0.84 16 2984 5 0 3 2 11
3G4S_9 0.50 0.39 0.67 22 7348 11 1 10 0 35
3GX2_A 0.68 0.55 0.85 22 4345 5 0 4 1 18
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IZ4_A 0.51 0.45 0.58 60 70772 50 4 40 6 72
3IZF_C 0.70 0.61 0.80 33 6862 8 1 7 0 21
3JYV_7 0.22 0.19 0.29 6 2829 15 0 15 0 26
3JYX_3 0.62 0.63 0.61 17 6300 22 1 10 11 10
3JYX_4 0.32 0.30 0.34 10 12217 31 3 16 12 23
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.78 0.65 0.94 30 6989 5 0 2 3 16
3O58_2 0.71 0.71 0.71 27 7222 12 4 7 1 11
3O58_3 0.35 0.34 0.35 12 12369 33 1 21 11 23
3PDR_A 0.77 0.64 0.94 46 12831 5 0 3 2 26
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4A1C_2 0.14 0.15 0.14 5 11745 42 5 26 11 28
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 1 6 0 14

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 396
Total TN 209673
Total FP 59
Total FP CONTRA 8
Total FP INCONS 29
Total FP COMP 22
Total FN 670
Total Scores
MCC 0.582
Average MCC ± 95% Confidence Intervals 0.536 ± 0.094
Sensitivity 0.371
Positive Predictive Value 0.915
Nr of predictions 28

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.73 0.55 1.00 6 400 0 0 0 0 5
2L94_A 0.00 0.00 0.00 0 990 0 0 0 0 20
2WRQ_Y 0.57 0.59 0.56 10 2832 13 5 3 5 7
2XKV_B 0.32 0.10 1.00 2 4558 1 0 0 1 18
2XQD_Y 0.79 0.63 1.00 17 2833 0 0 0 0 10
2XXA_G 0.27 0.07 1.00 3 5148 0 0 0 0 39
3A2K_C 0.78 0.61 1.00 17 2909 0 0 0 0 11
3AMU_B 0.69 0.59 0.80 16 2983 6 0 4 2 11
3G4S_9 0.50 0.28 0.89 16 7363 2 1 1 0 41
3GX2_A 0.57 0.33 1.00 13 4358 0 0 0 0 27
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IZ4_A 0.47 0.23 0.94 31 70843 2 0 2 0 101
3IZF_C 0.73 0.56 0.97 30 6872 1 0 1 0 24
3JYV_7 0.68 0.50 0.94 16 2833 1 0 1 0 16
3JYX_3 0.64 0.56 0.75 15 6308 10 1 4 5 12
3JYX_4 0.46 0.21 1.00 7 12239 2 0 0 2 26
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.44 0.20 1.00 9 7012 2 0 0 2 37
3O58_2 0.83 0.71 0.96 27 7232 2 0 1 1 11
3O58_3 0.51 0.26 1.00 9 12394 0 0 0 0 26
3PDR_A 0.62 0.40 0.97 29 12850 3 0 1 2 43
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.