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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & NanoFolder [.zip] - may take several seconds...


Overview

Metric Afold NanoFolder
MCC 0.411 > 0.395
Average MCC ± 95% Confidence Intervals 0.440 ± 0.566 > 0.434 ± 0.994
Sensitivity 0.467 < 0.517
Positive Predictive Value 0.373 > 0.313
Total TP 28 < 31
Total TN 6245 > 6221
Total FP 63 < 84
Total FP CONTRA 14 < 25
Total FP INCONS 33 < 43
Total FP COMP 16 = 16
Total FN 32 > 29
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and NanoFolder).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 28
Total TN 6245
Total FP 63
Total FP CONTRA 14
Total FP INCONS 33
Total FP COMP 16
Total FN 32
Total Scores
MCC 0.411
Average MCC ± 95% Confidence Intervals 0.440 ± 0.566
Sensitivity 0.467
Positive Predictive Value 0.373
Nr of predictions 3

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A

GP_knot1 links to Rfam database...

0.64 0.61 0.69 11 512 6 0 5 1 7
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4A1C_2

5_8S_rRNA links to Rfam database...

0.19 0.25 0.15 5 4483 43 11 17 15 15

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 31
Total TN 6221
Total FP 84
Total FP CONTRA 25
Total FP INCONS 43
Total FP COMP 16
Total FN 29
Total Scores
MCC 0.395
Average MCC ± 95% Confidence Intervals 0.434 ± 0.994
Sensitivity 0.517
Positive Predictive Value 0.313
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A

GP_knot1 links to Rfam database...

0.54 0.61 0.50 11 506 11 1 10 0 7
3U4M_B - 0.77 0.91 0.67 20 1246 12 6 4 2 2
4A1C_2

5_8S_rRNA links to Rfam database...

-0.01 0.00 0.00 0 4469 61 18 29 14 20

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

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