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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric Afold TurboFold(seed)
MCC 0.590 > 0.444
Average MCC ± 95% Confidence Intervals 0.638 ± 0.508 > 0.462 ± 0.716
Sensitivity 0.610 > 0.442
Positive Predictive Value 0.580 > 0.459
Total TP 47 > 34
Total TN 6301 < 6308
Total FP 52 = 52
Total FP CONTRA 11 < 12
Total FP INCONS 23 < 28
Total FP COMP 18 > 12
Total FN 30 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and TurboFold(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 47
Total TN 6301
Total FP 52
Total FP CONTRA 11
Total FP INCONS 23
Total FP COMP 18
Total FN 30
Total Scores
MCC 0.590
Average MCC ± 95% Confidence Intervals 0.638 ± 0.508
Sensitivity 0.610
Positive Predictive Value 0.580
Nr of predictions 4

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 6 0 5 1 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.19 0.25 0.15 5 4483 43 11 17 15 15
4ENB_A 0.81 0.73 0.92 11 460 3 0 1 2 4

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 34
Total TN 6308
Total FP 52
Total FP CONTRA 12
Total FP INCONS 28
Total FP COMP 12
Total FN 43
Total Scores
MCC 0.444
Average MCC ± 95% Confidence Intervals 0.462 ± 0.716
Sensitivity 0.442
Positive Predictive Value 0.459
Nr of predictions 4

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.