CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CRWrnafold - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CRWrnafold & Carnac(20) [.zip] - may take several seconds...


Overview

Metric CRWrnafold Carnac(20)
MCC 0.592 > 0.510
Average MCC ± 95% Confidence Intervals 0.646 ± 0.339 > 0.346 ± 0.413
Sensitivity 0.611 > 0.324
Positive Predictive Value 0.584 < 0.814
Total TP 66 > 35
Total TN 8341 < 8411
Total FP 68 > 10
Total FP CONTRA 18 > 2
Total FP INCONS 29 > 6
Total FP COMP 21 > 2
Total FN 42 < 73
P-value 0.0

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Performance plots


  1. Comparison of performance of CRWrnafold and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CRWrnafold and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CRWrnafold and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CRWrnafold and Carnac(20)).

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Performance of CRWrnafold - scored higher in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 66
Total TN 8341
Total FP 68
Total FP CONTRA 18
Total FP INCONS 29
Total FP COMP 21
Total FN 42
Total Scores
MCC 0.592
Average MCC ± 95% Confidence Intervals 0.646 ± 0.339
Sensitivity 0.611
Positive Predictive Value 0.584
Nr of predictions 5

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3SD1_A 0.63 0.66 0.61 19 1502 12 6 6 0 10
4A1C_2 0.19 0.25 0.15 5 4483 44 8 20 16 15
4AOB_A 0.71 0.69 0.74 20 1410 8 4 3 1 9
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.85 0.73 1.00 11 485 2 0 0 2 4

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 35
Total TN 8411
Total FP 10
Total FP CONTRA 2
Total FP INCONS 6
Total FP COMP 2
Total FN 73
Total Scores
MCC 0.510
Average MCC ± 95% Confidence Intervals 0.346 ± 0.413
Sensitivity 0.324
Positive Predictive Value 0.814
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.