CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Carnac(20) NanoFolder
MCC 0.463 > 0.285
Average MCC ± 95% Confidence Intervals 0.337 ± 0.755 < 0.346 ± 0.831
Sensitivity 0.297 < 0.359
Positive Predictive Value 0.731 > 0.240
Total TP 19 < 23
Total TN 6423 > 6353
Total FP 9 < 90
Total FP CONTRA 2 < 24
Total FP INCONS 5 < 49
Total FP COMP 2 < 17
Total FN 45 > 41
P-value 0.0

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Performance plots


  1. Comparison of performance of Carnac(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and NanoFolder).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 19
Total TN 6423
Total FP 9
Total FP CONTRA 2
Total FP INCONS 5
Total FP COMP 2
Total FN 45
Total Scores
MCC 0.463
Average MCC ± 95% Confidence Intervals 0.337 ± 0.755
Sensitivity 0.297
Positive Predictive Value 0.731
Nr of predictions 3

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 23
Total TN 6353
Total FP 90
Total FP CONTRA 24
Total FP INCONS 49
Total FP COMP 17
Total FN 41
Total Scores
MCC 0.285
Average MCC ± 95% Confidence Intervals 0.346 ± 0.831
Sensitivity 0.359
Positive Predictive Value 0.240
Nr of predictions 3

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.