CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) RNASampler(seed)
MCC 0.741 > 0.696
Average MCC ± 95% Confidence Intervals 0.712 ± 0.259 > 0.694 ± 0.282
Sensitivity 0.576 < 0.627
Positive Predictive Value 0.958 > 0.779
Total TP 68 < 74
Total TN 12511 > 12487
Total FP 5 < 34
Total FP CONTRA 0 < 9
Total FP INCONS 3 < 12
Total FP COMP 2 < 13
Total FN 50 > 44
P-value 0.0

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Performance plots


  1. Comparison of performance of Carnac(20) and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and RNASampler(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 68
Total TN 12511
Total FP 5
Total FP CONTRA 0
Total FP INCONS 3
Total FP COMP 2
Total FN 50
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.712 ± 0.259
Sensitivity 0.576
Positive Predictive Value 0.958
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3O58_3 0.60 0.36 1.00 8 4756 1 0 0 1 14
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 74
Total TN 12487
Total FP 34
Total FP CONTRA 9
Total FP INCONS 12
Total FP COMP 13
Total FN 44
Total Scores
MCC 0.696
Average MCC ± 95% Confidence Intervals 0.694 ± 0.282
Sensitivity 0.627
Positive Predictive Value 0.779
Nr of predictions 5

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3O58_3 0.54 0.50 0.58 11 4745 13 5 3 5 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.