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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) Multilign(seed)
MCC 0.867 > 0.755
Average MCC ± 95% Confidence Intervals 0.867 ± 0.050 > 0.767 ± 0.321
Sensitivity 0.768 > 0.707
Positive Predictive Value 0.984 > 0.817
Total TP 63 > 58
Total TN 3772 > 3765
Total FP 3 < 14
Total FP CONTRA 0 < 5
Total FP INCONS 1 < 8
Total FP COMP 2 > 1
Total FN 19 < 24
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Multilign(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 63
Total TN 3772
Total FP 3
Total FP CONTRA 0
Total FP INCONS 1
Total FP COMP 2
Total FN 19
Total Scores
MCC 0.867
Average MCC ± 95% Confidence Intervals 0.867 ± 0.050
Sensitivity 0.768
Positive Predictive Value 0.984
Nr of predictions 3

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 3765
Total FP 14
Total FP CONTRA 5
Total FP INCONS 8
Total FP COMP 1
Total FN 24
Total Scores
MCC 0.755
Average MCC ± 95% Confidence Intervals 0.767 ± 0.321
Sensitivity 0.707
Positive Predictive Value 0.817
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.