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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) PPfold(seed)
MCC 0.764 > 0.036
Average MCC ± 95% Confidence Intervals 0.731 ± 0.219 > 0.016 ± 0.042
Sensitivity 0.636 > 0.008
Positive Predictive Value 0.923 > 0.200
Total TP 84 > 1
Total TN 9229 < 9315
Total FP 11 < 23
Total FP CONTRA 3 > 0
Total FP INCONS 4 = 4
Total FP COMP 4 < 19
Total FN 48 < 131
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and PPfold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and PPfold(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 84
Total TN 9229
Total FP 11
Total FP CONTRA 3
Total FP INCONS 4
Total FP COMP 4
Total FN 48
Total Scores
MCC 0.764
Average MCC ± 95% Confidence Intervals 0.731 ± 0.219
Sensitivity 0.636
Positive Predictive Value 0.923
Nr of predictions 6

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
4A1C_2 0.33 0.25 0.45 5 4505 8 3 3 2 15
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 1
Total TN 9315
Total FP 23
Total FP CONTRA 0
Total FP INCONS 4
Total FP COMP 19
Total FN 131
Total Scores
MCC 0.036
Average MCC ± 95% Confidence Intervals 0.016 ± 0.042
Sensitivity 0.008
Positive Predictive Value 0.200
Nr of predictions 6

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.00 0.00 0.00 0 866 0 0 0 0 24
3SD1_A 0.00 0.00 0.00 0 1533 0 0 0 0 29
4A1C_2 0.10 0.05 0.20 1 4511 23 0 4 19 19
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.