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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) RNASampler(seed)
MCC 0.741 > 0.696
Average MCC ± 95% Confidence Intervals 0.710 ± 0.285 > 0.694 ± 0.282
Sensitivity 0.627 = 0.627
Positive Predictive Value 0.881 > 0.779
Total TP 74 = 74
Total TN 12498 > 12487
Total FP 13 < 34
Total FP CONTRA 6 < 9
Total FP INCONS 4 < 12
Total FP COMP 3 < 13
Total FN 44 = 44
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and RNASampler(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 74
Total TN 12498
Total FP 13
Total FP CONTRA 6
Total FP INCONS 4
Total FP COMP 3
Total FN 44
Total Scores
MCC 0.741
Average MCC ± 95% Confidence Intervals 0.710 ± 0.285
Sensitivity 0.627
Positive Predictive Value 0.881
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3IVN_B 0.86 0.83 0.90 19 882 2 2 0 0 4
3O58_3 0.64 0.45 0.91 10 4753 2 1 0 1 12
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
4A1C_2 0.33 0.25 0.45 5 4505 8 3 3 2 15

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 74
Total TN 12487
Total FP 34
Total FP CONTRA 9
Total FP INCONS 12
Total FP COMP 13
Total FN 44
Total Scores
MCC 0.696
Average MCC ± 95% Confidence Intervals 0.694 ± 0.282
Sensitivity 0.627
Positive Predictive Value 0.779
Nr of predictions 5

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3O58_3 0.54 0.50 0.58 11 4745 13 5 3 5 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.