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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

  4. Performance of ContextFold - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(seed) & ContextFold [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(seed) ContextFold
MCC 0.686 > 0.570
Average MCC ± 95% Confidence Intervals 0.587 ± 0.427 < 0.592 ± 0.249
Sensitivity 0.485 < 0.515
Positive Predictive Value 0.979 > 0.641
Total TP 47 < 50
Total TN 7401 > 7371
Total FP 5 < 42
Total FP CONTRA 1 < 6
Total FP INCONS 0 < 22
Total FP COMP 4 < 14
Total FN 50 > 47
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(seed) and ContextFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and ContextFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and ContextFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and ContextFold).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 47
Total TN 7401
Total FP 5
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 4
Total FN 50
Total Scores
MCC 0.686
Average MCC ± 95% Confidence Intervals 0.587 ± 0.427
Sensitivity 0.485
Positive Predictive Value 0.979
Nr of predictions 5

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.00 0.00 0.00 0 528 0 0 0 0 18
4A1C_2 0.60 0.40 0.89 8 4507 3 1 0 2 12
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.72 0.53 1.00 8 464 0 0 0 0 7
4ENC_A 0.73 0.53 1.00 8 488 0 0 0 0 7

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Performance of ContextFold - scored lower in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 50
Total TN 7371
Total FP 42
Total FP CONTRA 6
Total FP INCONS 22
Total FP COMP 14
Total FN 47
Total Scores
MCC 0.570
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249
Sensitivity 0.515
Positive Predictive Value 0.641
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.