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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(seed) Multilign(20)
MCC 0.810 > 0.581
Average MCC ± 95% Confidence Intervals 0.782 ± 0.128 > 0.583 ± 0.267
Sensitivity 0.674 > 0.576
Positive Predictive Value 0.978 > 0.598
Total TP 89 > 76
Total TN 9229 > 9193
Total FP 6 < 60
Total FP CONTRA 1 < 17
Total FP INCONS 1 < 34
Total FP COMP 4 < 9
Total FN 43 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and Multilign(20)).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 89
Total TN 9229
Total FP 6
Total FP CONTRA 1
Total FP INCONS 1
Total FP COMP 4
Total FN 43
Total Scores
MCC 0.810
Average MCC ± 95% Confidence Intervals 0.782 ± 0.128
Sensitivity 0.674
Positive Predictive Value 0.978
Nr of predictions 6

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
4A1C_2 0.60 0.40 0.89 8 4507 3 1 0 2 12
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.72 0.53 1.00 8 464 0 0 0 0 7
4ENC_A 0.73 0.53 1.00 8 488 0 0 0 0 7

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 9193
Total FP 60
Total FP CONTRA 17
Total FP INCONS 34
Total FP COMP 9
Total FN 56
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.583 ± 0.267
Sensitivity 0.576
Positive Predictive Value 0.598
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.