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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(seed) & RNASLOpt [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(seed) RNASLOpt
MCC 0.686 > 0.461
Average MCC ± 95% Confidence Intervals 0.587 ± 0.427 > 0.536 ± 0.307
Sensitivity 0.485 > 0.443
Positive Predictive Value 0.979 > 0.494
Total TP 47 > 43
Total TN 7401 > 7362
Total FP 5 < 53
Total FP CONTRA 1 < 17
Total FP INCONS 0 < 27
Total FP COMP 4 < 9
Total FN 50 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(seed) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(seed) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(seed) and RNASLOpt).

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Performance of CentroidAlifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(seed)

Total Base Pair Counts
Total TP 47
Total TN 7401
Total FP 5
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 4
Total FN 50
Total Scores
MCC 0.686
Average MCC ± 95% Confidence Intervals 0.587 ± 0.427
Sensitivity 0.485
Positive Predictive Value 0.979
Nr of predictions 5

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2. Individual counts for CentroidAlifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.00 0.00 0.00 0 528 0 0 0 0 18
4A1C_2 0.60 0.40 0.89 8 4507 3 1 0 2 12
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.72 0.53 1.00 8 464 0 0 0 0 7
4ENC_A 0.73 0.53 1.00 8 488 0 0 0 0 7

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 43
Total TN 7362
Total FP 53
Total FP CONTRA 17
Total FP INCONS 27
Total FP COMP 9
Total FN 54
Total Scores
MCC 0.461
Average MCC ± 95% Confidence Intervals 0.536 ± 0.307
Sensitivity 0.443
Positive Predictive Value 0.494
Nr of predictions 5

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.48 0.39 0.64 7 517 4 0 4 0 11
4A1C_2 0.30 0.40 0.24 8 4482 35 13 13 9 12
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.