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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidFold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidFold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidFold Multilign(seed)
MCC 0.659 > 0.629
Average MCC ± 95% Confidence Intervals 0.654 ± 0.307 > 0.569 ± 0.654
Sensitivity 0.610 > 0.580
Positive Predictive Value 0.726 > 0.699
Total TP 61 > 58
Total TN 4280 < 4281
Total FP 24 < 26
Total FP CONTRA 8 > 7
Total FP INCONS 15 < 18
Total FP COMP 1 = 1
Total FN 39 < 42
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidFold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and Multilign(seed)).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 61
Total TN 4280
Total FP 24
Total FP CONTRA 8
Total FP INCONS 15
Total FP COMP 1
Total FN 39
Total Scores
MCC 0.659
Average MCC ± 95% Confidence Intervals 0.654 ± 0.307
Sensitivity 0.610
Positive Predictive Value 0.726
Nr of predictions 4

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.51 0.39 0.70 7 518 3 1 2 0 11
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 4 4 0 9
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.