CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CentroidHomfold‑LAST		Cylofold
MCC	0.696	>	0.664
Average MCC ± 95% Confidence Intervals	0.615 ± 0.329	<	0.663 ± 0.246
Sensitivity	0.589	<	0.650
Positive Predictive Value	0.835	>	0.693
Total TP	96	<	106
Total TN	6904	>	6866
Total FP	21	<	49
Total FP CONTRA	2	<	13
Total FP INCONS	17	<	34
Total FP COMP	2	=	2
Total FN	67	>	57
P-value	0.0

Comparison of performance of CentroidHomfold-LAST and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and Cylofold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and Cylofold).

Total Scores
MCC	0.696
Average MCC ± 95% Confidence Intervals	0.615 ± 0.329
Sensitivity	0.589
Positive Predictive Value	0.835
Nr of predictions	8

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	-0.03	0.00	0.00	0	517	11	0	11	0	18
3J0L_a	-	-0.01	0.00	0.00	0	408	3	1	2	0	11
3RKF_A	Purine links to Rfam database...	0.86	0.75	1.00	18	848	0	0	0	0	6
3SD1_A	THF links to Rfam database...	0.77	0.66	0.90	19	1512	2	1	1	0	10
3U4M_B	-	0.78	0.73	0.84	16	1257	4	0	3	1	6
4AOB_A	SAM links to Rfam database...	0.85	0.72	1.00	21	1416	1	0	0	1	8
4ENB_A	crcB links to Rfam database...	0.85	0.73	1.00	11	461	0	0	0	0	4
4ENC_A	crcB links to Rfam database...	0.85	0.73	1.00	11	485	0	0	0	0	4

Total Scores
MCC	0.664
Average MCC ± 95% Confidence Intervals	0.663 ± 0.246
Sensitivity	0.650
Positive Predictive Value	0.693
Nr of predictions	8

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.64	0.61	0.69	11	512	5	1	4	0	7
3J0L_a	-	0.17	0.18	0.20	2	401	9	3	5	1	9
3RKF_A	Purine links to Rfam database...	0.91	0.83	1.00	20	846	0	0	0	0	4
3SD1_A	THF links to Rfam database...	0.71	0.69	0.74	20	1506	7	2	5	0	9
3U4M_B	-	0.49	0.55	0.46	12	1250	14	3	11	0	10
4AOB_A	SAM links to Rfam database...	0.42	0.38	0.48	11	1414	13	3	9	1	18
4ENB_A	crcB links to Rfam database...	1.00	1.00	1.00	15	457	0	0	0	0	0
4ENC_A	crcB links to Rfam database...	0.97	1.00	0.94	15	480	1	1	0	0	0

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.