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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of MXScarna(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & MXScarna(20) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST MXScarna(20)
MCC 0.726 > 0.606
Average MCC ± 95% Confidence Intervals 0.737 ± 0.258 > 0.580 ± 0.272
Sensitivity 0.644 > 0.561
Positive Predictive Value 0.825 > 0.667
Total TP 85 > 74
Total TN 9217 > 9209
Total FP 32 < 59
Total FP CONTRA 9 < 16
Total FP INCONS 9 < 21
Total FP COMP 14 < 22
Total FN 47 < 58
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and MXScarna(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and MXScarna(20)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 85
Total TN 9217
Total FP 32
Total FP CONTRA 9
Total FP INCONS 9
Total FP COMP 14
Total FN 47
Total Scores
MCC 0.726
Average MCC ± 95% Confidence Intervals 0.737 ± 0.258
Sensitivity 0.644
Positive Predictive Value 0.825
Nr of predictions 6

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.77 0.66 0.90 19 1512 2 1 1 0 10
4A1C_2 0.24 0.25 0.24 5 4495 29 8 8 13 15
4AOB_A 0.85 0.72 1.00 21 1416 1 0 0 1 8
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4

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Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 74
Total TN 9209
Total FP 59
Total FP CONTRA 16
Total FP INCONS 21
Total FP COMP 22
Total FN 58
Total Scores
MCC 0.606
Average MCC ± 95% Confidence Intervals 0.580 ± 0.272
Sensitivity 0.561
Positive Predictive Value 0.667
Nr of predictions 6

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.74 0.76 0.73 22 1503 9 6 2 1 7
4A1C_2 0.22 0.25 0.21 5 4492 36 8 11 17 15
4AOB_A 0.68 0.69 0.69 20 1408 13 2 7 4 9
4ENB_A 0.29 0.13 0.67 2 469 1 0 1 0 13
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.