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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST Multilign(seed)
MCC 0.682 > 0.629
Average MCC ± 95% Confidence Intervals 0.613 ± 0.682 > 0.569 ± 0.654
Sensitivity 0.580 = 0.580
Positive Predictive Value 0.817 > 0.699
Total TP 58 = 58
Total TN 4293 > 4281
Total FP 14 < 26
Total FP CONTRA 1 < 7
Total FP INCONS 12 < 18
Total FP COMP 1 = 1
Total FN 42 = 42
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and Multilign(seed)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 58
Total TN 4293
Total FP 14
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.682
Average MCC ± 95% Confidence Intervals 0.613 ± 0.682
Sensitivity 0.580
Positive Predictive Value 0.817
Nr of predictions 4

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 517 11 0 11 0 18
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.77 0.66 0.90 19 1512 2 1 1 0 10
4AOB_A 0.85 0.72 1.00 21 1416 1 0 0 1 8

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.