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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & PETfold_pre2.0(20) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST PETfold_pre2.0(20)
MCC 0.672 > 0.619
Average MCC ± 95% Confidence Intervals 0.699 ± 0.486 > 0.603 ± 0.416
Sensitivity 0.608 > 0.570
Positive Predictive Value 0.750 > 0.682
Total TP 48 > 45
Total TN 6857 > 6855
Total FP 30 < 33
Total FP CONTRA 8 > 2
Total FP INCONS 8 < 19
Total FP COMP 14 > 12
Total FN 31 < 34
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and PETfold_pre2.0(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and PETfold_pre2.0(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and PETfold_pre2.0(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and PETfold_pre2.0(20)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 48
Total TN 6857
Total FP 30
Total FP CONTRA 8
Total FP INCONS 8
Total FP COMP 14
Total FN 31
Total Scores
MCC 0.672
Average MCC ± 95% Confidence Intervals 0.699 ± 0.486
Sensitivity 0.608
Positive Predictive Value 0.750
Nr of predictions 4

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.24 0.25 0.24 5 4495 29 8 8 13 15
4AOB_A 0.85 0.72 1.00 21 1416 1 0 0 1 8
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4

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Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 45
Total TN 6855
Total FP 33
Total FP CONTRA 2
Total FP INCONS 19
Total FP COMP 12
Total FN 34
Total Scores
MCC 0.619
Average MCC ± 95% Confidence Intervals 0.603 ± 0.416
Sensitivity 0.570
Positive Predictive Value 0.682
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.