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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST RSpredict(20)
MCC 0.726 > 0.573
Average MCC ± 95% Confidence Intervals 0.737 ± 0.258 > 0.558 ± 0.276
Sensitivity 0.644 > 0.530
Positive Predictive Value 0.825 > 0.631
Total TP 85 > 70
Total TN 9217 > 9209
Total FP 32 < 48
Total FP CONTRA 9 < 19
Total FP INCONS 9 < 22
Total FP COMP 14 > 7
Total FN 47 < 62
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RSpredict(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and RSpredict(20)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 85
Total TN 9217
Total FP 32
Total FP CONTRA 9
Total FP INCONS 9
Total FP COMP 14
Total FN 47
Total Scores
MCC 0.726
Average MCC ± 95% Confidence Intervals 0.737 ± 0.258
Sensitivity 0.644
Positive Predictive Value 0.825
Nr of predictions 6

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.86 0.75 1.00 18 848 0 0 0 0 6
3SD1_A 0.77 0.66 0.90 19 1512 2 1 1 0 10
4A1C_2 0.24 0.25 0.24 5 4495 29 8 8 13 15
4AOB_A 0.85 0.72 1.00 21 1416 1 0 0 1 8
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 70
Total TN 9209
Total FP 48
Total FP CONTRA 19
Total FP INCONS 22
Total FP COMP 7
Total FN 62
Total Scores
MCC 0.573
Average MCC ± 95% Confidence Intervals 0.558 ± 0.276
Sensitivity 0.530
Positive Predictive Value 0.631
Nr of predictions 6

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 1 0 0 3
3SD1_A 0.82 0.86 0.78 25 1501 7 5 2 0 4
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.