CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Carnac(20) [.zip] - may take several seconds...


Overview

Metric ContextFold Carnac(20)
MCC 0.567 > 0.416
Average MCC ± 95% Confidence Intervals 0.596 ± 0.369 > 0.253 ± 0.477
Sensitivity 0.506 > 0.241
Positive Predictive Value 0.645 < 0.731
Total TP 40 > 19
Total TN 6859 < 6895
Total FP 36 > 9
Total FP CONTRA 6 > 2
Total FP INCONS 16 > 5
Total FP COMP 14 > 2
Total FN 39 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Carnac(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 40
Total TN 6859
Total FP 36
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 14
Total FN 39
Total Scores
MCC 0.567
Average MCC ± 95% Confidence Intervals 0.596 ± 0.369
Sensitivity 0.506
Positive Predictive Value 0.645
Nr of predictions 4

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 19
Total TN 6895
Total FP 9
Total FP CONTRA 2
Total FP INCONS 5
Total FP COMP 2
Total FN 60
Total Scores
MCC 0.416
Average MCC ± 95% Confidence Intervals 0.253 ± 0.477
Sensitivity 0.241
Positive Predictive Value 0.731
Nr of predictions 4

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.