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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & MCFold [.zip] - may take several seconds...


Overview

Metric ContextFold MCFold
MCC 0.673 > 0.436
Average MCC ± 95% Confidence Intervals 0.685 ± 0.257 > 0.437 ± 0.285
Sensitivity 0.614 > 0.475
Positive Predictive Value 0.747 > 0.414
Total TP 62 > 48
Total TN 7616 > 7583
Total FP 35 < 93
Total FP CONTRA 4 < 14
Total FP INCONS 17 < 54
Total FP COMP 14 < 25
Total FN 39 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and MCFold).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 62
Total TN 7616
Total FP 35
Total FP CONTRA 4
Total FP INCONS 17
Total FP COMP 14
Total FN 39
Total Scores
MCC 0.673
Average MCC ± 95% Confidence Intervals 0.685 ± 0.257
Sensitivity 0.614
Positive Predictive Value 0.747
Nr of predictions 6

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
3J0L_a - 0.80 0.73 0.89 8 402 2 0 1 1 3
3U4M_B - 0.98 0.95 1.00 21 1255 0 0 0 0 1
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 48
Total TN 7583
Total FP 93
Total FP CONTRA 14
Total FP INCONS 54
Total FP COMP 25
Total FN 53
Total Scores
MCC 0.436
Average MCC ± 95% Confidence Intervals 0.437 ± 0.285
Sensitivity 0.475
Positive Predictive Value 0.414
Nr of predictions 6

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
3J0L_a - 0.14 0.18 0.15 2 398 13 1 10 2 9
3U4M_B - 0.74 0.77 0.71 17 1252 10 1 6 3 5
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.