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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold PPfold(seed)
MCC 0.570 > 0.194
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249 > 0.118 ± 0.264
Sensitivity 0.515 > 0.072
Positive Predictive Value 0.641 > 0.538
Total TP 50 > 7
Total TN 7371 < 7436
Total FP 42 > 25
Total FP CONTRA 6 > 0
Total FP INCONS 22 > 6
Total FP COMP 14 < 19
Total FN 47 < 90
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and PPfold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and PPfold(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 50
Total TN 7371
Total FP 42
Total FP CONTRA 6
Total FP INCONS 22
Total FP COMP 14
Total FN 47
Total Scores
MCC 0.570
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249
Sensitivity 0.515
Positive Predictive Value 0.641
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 7
Total TN 7436
Total FP 25
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 19
Total FN 90
Total Scores
MCC 0.194
Average MCC ± 95% Confidence Intervals 0.118 ± 0.264
Sensitivity 0.072
Positive Predictive Value 0.538
Nr of predictions 5

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.49 0.33 0.75 6 520 2 0 2 0 12
4A1C_2 0.10 0.05 0.20 1 4511 23 0 4 19 19
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.