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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & RDfolder [.zip] - may take several seconds...


Overview

Metric ContextFold RDfolder
MCC 0.673 > 0.299
Average MCC ± 95% Confidence Intervals 0.700 ± 0.119 > 0.265 ± 0.328
Sensitivity 0.602 > 0.261
Positive Predictive Value 0.768 > 0.377
Total TP 53 > 23
Total TN 3275 < 3283
Total FP 18 < 39
Total FP CONTRA 3 < 9
Total FP INCONS 13 < 29
Total FP COMP 2 > 1
Total FN 35 < 65
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and RDfolder).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 53
Total TN 3275
Total FP 18
Total FP CONTRA 3
Total FP INCONS 13
Total FP COMP 2
Total FN 35
Total Scores
MCC 0.673
Average MCC ± 95% Confidence Intervals 0.700 ± 0.119
Sensitivity 0.602
Positive Predictive Value 0.768
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
3J0L_a - 0.80 0.73 0.89 8 402 2 0 1 1 3
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 23
Total TN 3283
Total FP 39
Total FP CONTRA 9
Total FP INCONS 29
Total FP COMP 1
Total FN 65
Total Scores
MCC 0.299
Average MCC ± 95% Confidence Intervals 0.265 ± 0.328
Sensitivity 0.261
Positive Predictive Value 0.377
Nr of predictions 5

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 514 14 3 11 0 18
3J0L_a - -0.02 0.00 0.00 0 407 4 3 1 0 11
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 0.48 0.40 0.60 6 462 4 0 4 0 9
4ENC_A 0.48 0.40 0.60 6 486 4 0 4 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.