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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric ContextFold RSpredict(20)
MCC 0.567 > 0.351
Average MCC ± 95% Confidence Intervals 0.596 ± 0.369 > 0.404 ± 0.223
Sensitivity 0.506 > 0.304
Positive Predictive Value 0.645 > 0.421
Total TP 40 > 24
Total TN 6859 < 6864
Total FP 36 < 40
Total FP CONTRA 6 < 13
Total FP INCONS 16 < 20
Total FP COMP 14 > 7
Total FN 39 < 55
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and RSpredict(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and RSpredict(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 40
Total TN 6859
Total FP 36
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 14
Total FN 39
Total Scores
MCC 0.567
Average MCC ± 95% Confidence Intervals 0.596 ± 0.369
Sensitivity 0.506
Positive Predictive Value 0.645
Nr of predictions 4

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 24
Total TN 6864
Total FP 40
Total FP CONTRA 13
Total FP INCONS 20
Total FP COMP 7
Total FN 55
Total Scores
MCC 0.351
Average MCC ± 95% Confidence Intervals 0.404 ± 0.223
Sensitivity 0.304
Positive Predictive Value 0.421
Nr of predictions 4

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.