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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of RSpredict(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & RSpredict(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold RSpredict(seed)
MCC 0.570 > 0.203
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249 > 0.211 ± 0.261
Sensitivity 0.515 > 0.124
Positive Predictive Value 0.641 > 0.353
Total TP 50 > 12
Total TN 7371 < 7415
Total FP 42 > 23
Total FP CONTRA 6 > 2
Total FP INCONS 22 > 20
Total FP COMP 14 > 1
Total FN 47 < 85
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and RSpredict(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and RSpredict(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 50
Total TN 7371
Total FP 42
Total FP CONTRA 6
Total FP INCONS 22
Total FP COMP 14
Total FN 47
Total Scores
MCC 0.570
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249
Sensitivity 0.515
Positive Predictive Value 0.641
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP 12
Total TN 7415
Total FP 23
Total FP CONTRA 2
Total FP INCONS 20
Total FP COMP 1
Total FN 85
Total Scores
MCC 0.203
Average MCC ± 95% Confidence Intervals 0.211 ± 0.261
Sensitivity 0.124
Positive Predictive Value 0.353
Nr of predictions 5

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
4A1C_2 0.00 0.00 0.00 0 4512 5 2 2 1 20
4AOB_A 0.42 0.21 0.86 6 1430 1 0 1 0 23
4ENB_A 0.34 0.20 0.60 3 467 2 0 2 0 12
4ENC_A 0.34 0.20 0.60 3 491 2 0 2 0 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.