CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Contrafold Multilign(20)
MCC 0.628 > 0.581
Average MCC ± 95% Confidence Intervals 0.666 ± 0.272 > 0.583 ± 0.267
Sensitivity 0.621 > 0.576
Positive Predictive Value 0.646 > 0.598
Total TP 82 > 76
Total TN 9193 = 9193
Total FP 59 < 60
Total FP CONTRA 19 > 17
Total FP INCONS 26 < 34
Total FP COMP 14 > 9
Total FN 50 < 56
P-value 0.0

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Performance plots


  1. Comparison of performance of Contrafold and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Multilign(20)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 82
Total TN 9193
Total FP 59
Total FP CONTRA 19
Total FP INCONS 26
Total FP COMP 14
Total FN 50
Total Scores
MCC 0.628
Average MCC ± 95% Confidence Intervals 0.666 ± 0.272
Sensitivity 0.621
Positive Predictive Value 0.646
Nr of predictions 6

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 9193
Total FP 60
Total FP CONTRA 17
Total FP INCONS 34
Total FP COMP 9
Total FN 56
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.583 ± 0.267
Sensitivity 0.576
Positive Predictive Value 0.598
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.