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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Contrafold Multilign(seed)
MCC 0.646 > 0.629
Average MCC ± 95% Confidence Intervals 0.635 ± 0.287 > 0.569 ± 0.654
Sensitivity 0.620 > 0.580
Positive Predictive Value 0.689 < 0.699
Total TP 62 > 58
Total TN 4274 < 4281
Total FP 29 > 26
Total FP CONTRA 13 > 7
Total FP INCONS 15 < 18
Total FP COMP 1 = 1
Total FN 38 < 42
P-value 0.0

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Performance plots


  1. Comparison of performance of Contrafold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Multilign(seed)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 62
Total TN 4274
Total FP 29
Total FP CONTRA 13
Total FP INCONS 15
Total FP COMP 1
Total FN 38
Total Scores
MCC 0.646
Average MCC ± 95% Confidence Intervals 0.635 ± 0.287
Sensitivity 0.620
Positive Predictive Value 0.689
Nr of predictions 4

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.46 0.39 0.58 7 516 5 3 2 0 11
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.