CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & NanoFolder [.zip] - may take several seconds...


Overview

Metric Contrafold NanoFolder
MCC 0.542 > 0.427
Average MCC ± 95% Confidence Intervals 0.572 ± 0.328 > 0.470 ± 0.376
Sensitivity 0.529 > 0.519
Positive Predictive Value 0.567 > 0.365
Total TP 55 > 54
Total TN 8156 > 8105
Total FP 57 < 113
Total FP CONTRA 15 < 31
Total FP INCONS 27 < 63
Total FP COMP 15 < 19
Total FN 49 < 50
P-value 0.0

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Performance plots


  1. Comparison of performance of Contrafold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and NanoFolder).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 55
Total TN 8156
Total FP 57
Total FP CONTRA 15
Total FP INCONS 27
Total FP COMP 15
Total FN 49
Total Scores
MCC 0.542
Average MCC ± 95% Confidence Intervals 0.572 ± 0.328
Sensitivity 0.529
Positive Predictive Value 0.567
Nr of predictions 5

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.46 0.39 0.58 7 516 5 3 2 0 11
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 54
Total TN 8105
Total FP 113
Total FP CONTRA 31
Total FP INCONS 63
Total FP COMP 19
Total FN 50
Total Scores
MCC 0.427
Average MCC ± 95% Confidence Intervals 0.470 ± 0.376
Sensitivity 0.519
Positive Predictive Value 0.365
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
3U4M_B - 0.77 0.91 0.67 20 1246 12 6 4 2 2
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.