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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Cylofold Multilign(20)
MCC 0.756 > 0.678
Average MCC ± 95% Confidence Intervals 0.801 ± 0.302 > 0.661 ± 0.237
Sensitivity 0.723 > 0.634
Positive Predictive Value 0.802 > 0.740
Total TP 81 > 71
Total TN 4703 < 4708
Total FP 21 < 27
Total FP CONTRA 6 < 8
Total FP INCONS 14 < 17
Total FP COMP 1 < 2
Total FN 31 < 41
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and Multilign(20)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 81
Total TN 4703
Total FP 21
Total FP CONTRA 6
Total FP INCONS 14
Total FP COMP 1
Total FN 31
Total Scores
MCC 0.756
Average MCC ± 95% Confidence Intervals 0.801 ± 0.302
Sensitivity 0.723
Positive Predictive Value 0.802
Nr of predictions 5

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 71
Total TN 4708
Total FP 27
Total FP CONTRA 8
Total FP INCONS 17
Total FP COMP 2
Total FN 41
Total Scores
MCC 0.678
Average MCC ± 95% Confidence Intervals 0.661 ± 0.237
Sensitivity 0.634
Positive Predictive Value 0.740
Nr of predictions 5

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.68 0.69 0.69 20 1504 9 4 5 0 9
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.