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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold Multilign(seed)
MCC 0.661 > 0.629
Average MCC ± 95% Confidence Intervals 0.668 ± 0.325 > 0.569 ± 0.654
Sensitivity 0.620 > 0.580
Positive Predictive Value 0.721 > 0.699
Total TP 62 > 58
Total TN 4278 < 4281
Total FP 25 < 26
Total FP CONTRA 6 < 7
Total FP INCONS 18 = 18
Total FP COMP 1 = 1
Total FN 38 < 42
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and Multilign(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 62
Total TN 4278
Total FP 25
Total FP CONTRA 6
Total FP INCONS 18
Total FP COMP 1
Total FN 38
Total Scores
MCC 0.661
Average MCC ± 95% Confidence Intervals 0.668 ± 0.325
Sensitivity 0.620
Positive Predictive Value 0.721
Nr of predictions 4

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.