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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & NanoFolder [.zip] - may take several seconds...


Overview

Metric Cylofold NanoFolder
MCC 0.585 > 0.576
Average MCC ± 95% Confidence Intervals 0.628 ± 0.388 > 0.589 ± 0.264
Sensitivity 0.583 < 0.643
Positive Predictive Value 0.605 > 0.535
Total TP 49 < 54
Total TN 3656 > 3636
Total FP 33 < 52
Total FP CONTRA 8 < 13
Total FP INCONS 24 < 34
Total FP COMP 1 < 5
Total FN 35 > 30
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and NanoFolder).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 49
Total TN 3656
Total FP 33
Total FP CONTRA 8
Total FP INCONS 24
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.585
Average MCC ± 95% Confidence Intervals 0.628 ± 0.388
Sensitivity 0.583
Positive Predictive Value 0.605
Nr of predictions 4

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A

GP_knot1 links to Rfam database...

0.64 0.61 0.69 11 512 5 1 4 0 7
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4AOB_A

SAM links to Rfam database...

0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENC_A

crcB links to Rfam database...

0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 54
Total TN 3636
Total FP 52
Total FP CONTRA 13
Total FP INCONS 34
Total FP COMP 5
Total FN 30
Total Scores
MCC 0.576
Average MCC ± 95% Confidence Intervals 0.589 ± 0.264
Sensitivity 0.643
Positive Predictive Value 0.535
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A

GP_knot1 links to Rfam database...

0.54 0.61 0.50 11 506 11 1 10 0 7
3U4M_B - 0.77 0.91 0.67 20 1246 12 6 4 2 2
4AOB_A

SAM links to Rfam database...

0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A

crcB links to Rfam database...

0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

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