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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of PETfold_pre2.0(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & PETfold_pre2.0(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold PETfold_pre2.0(seed)
MCC 0.701 > 0.666
Average MCC ± 95% Confidence Intervals 0.755 ± 0.445 > 0.622 ± 0.286
Sensitivity 0.675 > 0.584
Positive Predictive Value 0.743 < 0.776
Total TP 52 > 45
Total TN 2863 < 2875
Total FP 19 = 19
Total FP CONTRA 5 > 2
Total FP INCONS 13 > 11
Total FP COMP 1 < 6
Total FN 25 < 32
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and PETfold_pre2.0(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and PETfold_pre2.0(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and PETfold_pre2.0(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and PETfold_pre2.0(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 52
Total TN 2863
Total FP 19
Total FP CONTRA 5
Total FP INCONS 13
Total FP COMP 1
Total FN 25
Total Scores
MCC 0.701
Average MCC ± 95% Confidence Intervals 0.755 ± 0.445
Sensitivity 0.675
Positive Predictive Value 0.743
Nr of predictions 4

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of PETfold_pre2.0(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 45
Total TN 2875
Total FP 19
Total FP CONTRA 2
Total FP INCONS 11
Total FP COMP 6
Total FN 32
Total Scores
MCC 0.666
Average MCC ± 95% Confidence Intervals 0.622 ± 0.286
Sensitivity 0.584
Positive Predictive Value 0.776
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 0 5 0 12
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.