CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & RNASLOpt [.zip] - may take several seconds...


Overview

Metric Cylofold RNASLOpt
MCC 0.602 > 0.493
Average MCC ± 95% Confidence Intervals 0.614 ± 0.340 > 0.514 ± 0.255
Sensitivity 0.600 > 0.445
Positive Predictive Value 0.623 > 0.570
Total TP 66 > 49
Total TN 4514 < 4534
Total FP 42 > 38
Total FP CONTRA 11 > 10
Total FP INCONS 29 > 27
Total FP COMP 2 > 1
Total FN 44 < 61
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and RNASLOpt).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 66
Total TN 4514
Total FP 42
Total FP CONTRA 11
Total FP INCONS 29
Total FP COMP 2
Total FN 44
Total Scores
MCC 0.602
Average MCC ± 95% Confidence Intervals 0.614 ± 0.340
Sensitivity 0.600
Positive Predictive Value 0.623
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
3J0L_a - 0.17 0.18 0.20 2 401 9 3 5 1 9
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4AOB_A 0.42 0.38 0.48 11 1414 13 3 9 1 18
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 49
Total TN 4534
Total FP 38
Total FP CONTRA 10
Total FP INCONS 27
Total FP COMP 1
Total FN 61
Total Scores
MCC 0.493
Average MCC ± 95% Confidence Intervals 0.514 ± 0.255
Sensitivity 0.445
Positive Predictive Value 0.570
Nr of predictions 6

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.48 0.39 0.64 7 517 4 0 4 0 11
3J0L_a - 0.21 0.18 0.29 2 404 6 3 2 1 9
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.